The first organizations of Young Men's Christian Associations in America were formed in Montreal and Boston in 1851, following the plan of a society organized in England in 1844. Although an effort was made in Jackson as early as April 6, 1860, to organize a Young Men's Christian Association, the present Young Men's Christian Association came into being at a meeting held in the First Baptist Church, on April 9, 1905. The formal charter was issued to the Young Men's Christian Association on December 14, 1906. Since that time, the YMCA has been a vital part of Jackson's progress as a Christian community. The collection contains:

• correspondence and photographs concerning Castalian Springs Camp, Durant, April 15, 1965–July 31, 1967 (folders 1–3)
• printed materials concerning the Blake W. Godfrey Chapter and a writing by Blake W. Godfrey (folder 4)
• a brief history of the Girls Work of the Mississippi State YMCA, April 12, 1922 (folder 5)
• minutes of the meeting of the State Executive Committee of the State Council of the Mississippi YMCA, March 31, 1926 (folder 6)
• a summary report by Henry T. Ware, concerning the history organization, and program of the State Teachers College "Y," March, 1938 (folder 7)
• notes on meetings of Mississippi State YMCA Staff, Blue Ridge, N.C., July 5–20, 1919 (folder 8)
• news clippings and a pamphlet entitled Southern High School Boys' Conference (folder 9)
• financial statements, January 1, 1920–December 23, 1926 (folder 10)
• information for delegates to the Constitutional Convention interested in the town and country field and material concerning the August Meeting of the YMCA Board of Directors, September 13, 1938 (folder 11)
• a statement from the Mississippi State Young Men's Christian Association related to the conditions caused by the Mississippi River flood (folder 12)
• camp songs of the Girls' Hi-Y. Training Camp Conference, Deer Island, June 15–23, 1921, and a list of s\"Y-Godfathers," 1923–1925 (folder 13)